Topical delivery of therapeutic agents using cell

Topical delivery of therapeutic agents using cell

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Topical Delivery of Protein and Peptide Using Novel Cell

18/5/2016· Kamada H. et al. Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain. Biol Pharm Bull 30, 218223 (2007). [] Rothbard J. B. et al. Conjugation of arginine.

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Topical and Targeted Delivery of siRNAs to Melanoma

Topical application of siRNAs through the skin is a potentially effective strategy for the treatment of melanoma tumors. In this study, we designed a new and safe fusion peptide carrier SPACE-EGF ...

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Cell-penetrating peptide-based non-invasive topical

Cell-penetrating peptides (CPPs) have been receiving much attention over the last few decades due to their unique ability to translocate across plasma membranes efficiently and carry the wide range of macromolecular cargoes with them. Although their intracellular delivery mechanism has not been fully elucidated, CPP-based cellular uptake, mainly mediated by direct transduction or endocytosis ...

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Topical Drug Delivery perio Flashcards Quizlet

Start studying Topical Drug Delivery perio. Learn vocabulary, terms, and more with flashcards, games, and other study tools.-when home care regimens fail to achieve plaque control goals-addition to perio instrumentation-OH inadequate due to patient being

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Topical delivery of low-cost protein drug candidates

Topical delivery of low-cost protein drug candidates made in chloroplasts for biofilm disruption and uptake by oral epithelial cells ... Therapeutic agents need to be effective following topical applications to either prevent biofilm formation or disrupt formed biofilms it ...

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Method and device for topical delivery of therapeutic

8/1/2008· A method of delivering a therapeutic agent to the skin comprising loading one or more therapeutic agents into microchannels passing through a flexible porous polymer open cell foam material, and a polymer enrobing material which is in contact with the skin and

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(PDF) Topical Delivery of Anti-VEGF Drugs to the Ocular

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides ... novel approaches for noninvasive delivery of potent therapeutic agents are on the rise. In ...

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Topical delivery of nucleic acids in the skin

1 Topical delivery of nucleic acids in the skin V. Préat*, N. Dujardin Université catholique de Louvain, Unité de pharmacie galénique, Avenue Mounier, 73 UCL 7320, 1200 Brussels, Belgium *Correspondence: [email protected] The skin is an attractive site for the ...

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Thermo-sensitive, mucoadhesive or dermoadhesive, and

16/6/2015· Thermo-sensitive, mucoadhesive or dermoadhesive, and penetration-enhancing formulations for topical delivery of therapeutics ... optionally, one or more therapeutic agents. Also provided are uses of the biopolymer formulations for topical therapy of cancer ...

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Topical delivery of therapeutic agents in the treatment of

For targeting local and systemic inflammatory processes in inflammatory bowel disease (IBD) therapeutic agents of first choice (e.g. aminosalicylates, corticosteroids) have been developed in special galenic forms to accomplish the topical delivery of the active ...

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New Formulation Strategies in Topical Antifungal Therapy

New Formulation Strategies in Topical Antifungal Therapy 59 reference conventional formulation of ketaconazole. The safety of microemulsion formulations of ketoconazole for topical use has also been showed according to histo- pathological data on rat skin [33].

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WO2005067499A2 - Method and device for topical

A composite sheet for delivering therapeutic agents to the skin and method of use is disclosed. The composite sheet comprises a flexible porous polymer for holding and releasing the therapeutic agent in a polymer enrobing material. Micro-channels pass through the ...

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MedicalResearch.com New Technology May Allow

New Technology May Allow Topical Delivery of Anti-VEGF Drugs For Macular Degeneration Posted at 21:04h in Author Interviews, Macular Degeneration, Ophthalmology, Technology by Marie Benz MD FAAD 1 Comment MedicalResearch.com Interview with: ...

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US20140018435A1 - Transdermal Delivery of

US20140018435A1 - Transdermal Delivery of Therapeutic Agents Using Poly (Amidoamine) Dendrimers - Google Patents Transdermal Delivery of Therapeutic Agents Using Poly (Amidoamine) Dendrimers Download PDF Info Publication number US13/906,009 ...

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Formulations and Methods For Targeted Ocular Delivery

27/10/2016· Formulations and Methods For Targeted Ocular Delivery of Therapeutic Agents United States Patent Application 20160310417 ... intravitreal, and periocular administrations. Topical delivery is the mainstay to deliver drugs to the anterior segment, but only acts ...

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Update of Ablative Fractionated Lasers to Enhance

REVIEW Update of Ablative Fractionated Lasers to Enhance Cutaneous Topical Drug Delivery Jill S. Waibel. Ashley Rudnick. Deborah R. Shagalov. Danielle M. Nicolazzo Received: August 25, 2016/Published online: July 7, 2017 The Author(s) 2017. This article is

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Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell

Original Article Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide Davide Schiroli, 1María J. Gómara,2 Eleonora Maurizi, Sarah D. Atkinson,1,3 Laura Mairs, 1Kathleen A. Christie, ...

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Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides Felicity de Cogan,1 Lisa J. Hill,1 Aisling Lynch,2 Peter J. Morgan-Warren,1 Judith Lechner,2 Matthew R. Berwick,3 Anna F. A. Peacock,3 Mei Chen ...

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Topical medication - Wikipedia

A topical medication is a medication that is applied to a particular place on or in the body. Most often topical administration means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments.[1] Many topical medications are ...

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Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides Felicity de Cogan,1 Lisa J. Hill,1 Aisling Lynch,2 Peter J. Morgan-Warren,1 Judith Lechner,2 Matthew R. Berwick,3 Anna F. A. Peacock,3 Mei Chen,2 4 2 1

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US Patent Application for TOPICAL DELIVERY OF

Justia Patents US Patent Application for TOPICAL DELIVERY OF THERAPEUTIC AGENTS USING CELL-PENETRATING PEPTIDES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER EYE DISEASES Patent Application (Application #20190015521) ...

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Topical Drug Delivery to the Posterior Segment of the

Topical delivery of therapeutics to the posterior segment of the eye remains the holy grail of ocular drug delivery. As an example, antivascular endothelial growth factor biologics, such as ranibizumab, aflibercept, and bevacizumab, are delivered by intravitreal injection to treat neovascular age-related macular degeneration and, although these drugs have revolutionized treatment of ...

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Update of Ablative Fractionated Lasers to Enhance

Ablative fractional lasers (AFXL) enhance uptake of therapeutics and this newly emerging field is called laser-assisted drug delivery (LAD). This new science has emerged over the past decade and is finding its way into clinical practice. LAD is poised to change how medicine delivers drugs. Topical and systemic application of pharmaceutical agents for therapeutic effect is an integral part of ...

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Topical Therapy for the Treatment of Basal Cell Carcinoma

Nguyen B, Gan S, Konnikov N, et al. Treatment of superficial basal cell carcinoma and squamous cell carcinoma in situ on the trunk and extremities with ablative fractional laser-assisted delivery of topical fluorouracil. J Am Acad Dermatol. 2015;72:55860.

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Gellan gum-based delivery systems of therapeutic

The purpose of this review is to make a summary of high quality research trends using gellan gum (GG) as a polymeric constituent for the design of innovative drug delivery systems and devices for biomedical applications, such as cell therapy and regenerative ...

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Biocompatible polymer microneedle for topical/dermal

As there is, of course, no single method of drug delivery that is equally effective in and applicable to all cases, a large body of research aims to find optimal solutions for particular drug delivery problems, including the local delivery of therapeutic agents using

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US20080131493A1 - Method and Multilayered Device for

A multilayered composite sheet for delivering one or more therapeutic agents to the skin is disclosed. The composite sheet comprises a flexible porous polymer with open cells of a sufficient size for holding a therapeutic agent, an encapsulating agent for ...

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Nanoparticles and nanofibers for topical drug delivery -

6. Formulation of nanoparticles and nanofibers for topical application in the clinic Topical drug delivery vehicles (e.g., nanoparticles and nanofibers) can provide therapeutic action directly to the targeted site, potentially reducing unwanted systemic side effects.

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Conjugation of arginine oligomers to cyclosporin A

The skin offers a formidable barrier to the delivery of large and small molecular therapeutic agents 1,2,3,4.The basis for this barrier has been studied extensively and has been found to reside ...

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Transdermal delivery of therapeutic agents using

Transdermal delivery of therapeutic agents using dendrimers (US20140018435A1): A patent evaluation Article in Expert Opinion on Therapeutic Patents 25(10):1-6 · July 2015 with 36 Re ...

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l c a l Derma Journal of Clinical & Experimental t i n o i lo f o l

Topical Delivery of Lipid Based Amphotericin B Gel in the Treatment of Fungal Infection: A Clinical Efficacy, Safety and Tolerability Study in Patients Saifuddin Sheikh 1, Ateeq Ahmad , Shoukath M Ali , Mahesh Paithankar 2, Hanmant Barkate , Ranjan C Raval 3, Kalpesh Shah4, Bhavik A Bhavsar 5, Radha ...

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Transdermal and Topical Drug Delivery Request PDF

Request PDF On Jan 1, 2003, A.C. Williams and others published Transdermal and Topical Drug Delivery ... layer of the skin and create a pathway to deliver the therapeutic agents, they could also ...

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